Our group is developing and using microfluidic large-scale integration (mLSI) chip technology for characterizing biomolecules and their interactions within regulatory signaling network of cells and whole organisms. The hallmarks of the platforms are pneumatic membrane valves for fluid routing, metering, and controlling reaction kinetics in small volumes. Compared to conventional platforms, mLSI chip-based chips provide several advantages such as full automation and multiplexing, enhanced precision, control and throughput, high spatial and temporal resolution. We are interested in designing new fluid circuitries, investigating new materials compatible for mLSI applications, interfacing chips to standard labware and high throughput readout instrumentation (imaging, or sequencing).NilsChip_Low                                     mLSI Chip for Adult Stem Cell Differentiation


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